Tuesday, June 20, 2006

Labetolol dose

Tuesday June 20, 2006

Labetolol dose

Q: What is the usual guided dose of labetalol in hypertensive emergency ?

A; Loading dose of 0.25 mg/kg followed by 0.5 mg/kg every 15 minutes but total dose should remain less than 3.25 mg/kg.

Advantage of Labetalol:

  • Action within 5 minutes and
  • combined alpha and beta blocker effect

Disadvantage of Labetalol:

  • It decreases both SVR (Systemic Vascular Resistance) and CO (Cardiac Output).

(From Dr. Joseph Varon's lecture "Hypertensive Emergencies in the Perioperative Cardiovascular Setting" at Hypertensive Crisis: Strategies To minimize End-Organ Damage With Focus On The Heart and Brain - symposium during Chest 2005)