Tuesday November 8, 2005
Troponin-I or Troponin-T ?

As picture is getting more clear about Troponins, it appears that Troponin-I does not get affected with renal insufficiency/failure. While 'sustained' elevated Troponin-T reflects poor cardiac baseline and predicts poor overall cardiac mortality. If Troponin-I is not available in your hospital, a spike (bell curve) or continuously rising Troponin-T may be an indicator of acute coronary event but low level sustained value may just reflect baseline cardiac decompensation.

Refrences: click on link to get article/abstract
1. Clinical Association between Renal Insufficiency and Positive Troponin I in Patients with Acute Coronary Syndrome - Cardiology 2004;102:215-219
2. Cardiac troponin-I before and after renal dialysis - Clinical Nephrology, Vol. 54 - No. 3/200
3. Troponin is related to left ventricular mass and predicts all-cause and cardiovascular mortality in hemodialysis patients. - Am J Kidney Dis. 2002 Jul;40(1):68-75.