Monday, July 03, 2006

Monday July 3, 2006
Simplify D-dimer

D-dimer has great negative predictive value in excluding pulmonary embolism (PE) or deep vein thrombosis (DVT). So far we had to send blood for laboratory-based quantitative D-dimer.

Simplify D-dimer is a new version of test which can be performed at bedside quickly and can provide instant clue
1. Check
here to see details on test, that can be performed with a drop of blood at bedside.

Recently in chest, Dr. Kline and coll. from Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC reported that the posttest prevalence of PE among low-risk patients with negative d-dimer results by simplify D-dimer Assay was only 0.7% 2, supplementing the previous famous study on d-dimer by Dr. Wells 3.

Related previous pearls:
Wells Score of DVT ,
What if even thrombolysis fails in massive PE ?

References: click to get abstract/article

1. A new rapid bedside assay for D-dimer measurement (Simplify D-dimer) in the diagnostic work-up for deep vein thrombosis - J Thromb Haemost. 2003 Dec;1(12):2681-3.

Prospective Study of the Diagnostic Accuracy of the Simplify D-dimer Assay for Pulmonary Embolism in Emergency Department Patients Chest. 2006;129:1417-1423.)

Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and D-dimer - 17 July 2001 Volume 135 Issue 2 Pages 98-107, Annals