Friday, October 14, 2005


Friday October 14, 2005

1. ARMA study: In patients with ALI / ARDS, lower TV (6 ml/kg of ideal body weight) results in decreased mortality and increases days without ventilator.1

2. ALVEOLI Study: In patients with ALI / ARDS, clinical outcomes are same whether lower or higher PEEP levels are used (with low TV and limited PlPr). 2

3. KARMA Study: In patients with ALI / ARDS, ketoconazole did not reduce mortality or duration of mechanical ventilation or improve lung function. 3

4. LARMA Study: lisofylline had no beneficial effects in ALI / ARDS. 4

5. LATE STERIOD RESCUE STUDY (LaSRS): The Efficacy of steroids as Rescue Therapy for the Late Phase of ARDS - Publication pending.

6. FACTT Study - 2 parts : - Ongoing Trial
1) Swan(PAC) vs Central Venous Catheter for Management of ALI / ARDS.
2) "Fluid Conservative" vs "Fluid Liberal" Management of ALI / ARDS) 5

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome - N Engl J Med. 2000;342:1301-1308
Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome - N Engl J Med 2004;351:327-336
Ketoconazole for Early Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome - JAMA, 2000;283:1995-2002
Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and ARDS - Crit Care Med. 2002; 30(1):1-6
Protocol details - FACTT Trial - ARDSnet