Sunday, November 20, 2005

Sunday November 20, 2005
Time lag between Linezolid and Thrombocytopenia

Thrombocytopenia could be multifactorial in ICU. One of the relative new cause is Linezolid (Zyvox). But thrombocytopenia with Zyvox usually doesn't occur upto 2 weeks with the initiation of treatment and could help in ruling out atleast one reason. Relatively overall its mild, reversible and due to myelosuppression. there is no evidence for anti-platelet or interference with platelet function.

References: click to get abstract/article
Hematologic Effects of Linezolid: Summary of Clinical Experience - Antimicrobial Agents and Chemotherapy, August 2002, p. 2723-2726, Vol. 46, No. 8
Linezolid and reversible myelosuppression. - JAMA 285:1291
Safety, efficacy and pharmacokinetics of linezolid for treatment of resistant Gram-positive infections in cancer patients with neutropenia - Annals of Oncology 14:795-801, 2003